HomehealthResearchers discover new antibodies that can suppress HIV
Researchers say they have discovered an HIV antibody that can suppress the virus for almost six months without additional treatment. The new study involved approximately half of a group of monkeys infused with a largely neutralizing antibody to HIV combined with an immunostimulant
The results reported at the 25th Conference on Retroviruses and Opportunistic Infections in Boston an indication of strategies that seek to achieve a permanent, drug-free virus remission in people living with HIV. Supported in part by the US National Institute for Allergy and Infectious Diseases, NIAID, the study could target the virus reservoir, populations of long-lived, latently infected cells that harbor the virus and which lead to resurgent virus replication when suppressive therapy was stopped.
“HIV transcends the immune system by hiding in certain immune cells,” said NIAID director Anthony Fauci.
“The virus can b In antiretroviral therapy, the levels are lowered to a very low level, but quickly return to high levels when a person discontinues the prescription treatment.”
“Deliver the results of this early phase of research More Evidence That Persistent Viral Remission Can Be Achieved Without Daily Medication “In this study, Beth Israel Deaconess Medical Center scientists infected 44 rhesus macaques with the Simian Human Immunodeficiency Virus (SHIV), an HIV-like virus commonly found in non-human primate studies is used.
They then initiated a daily antiretroviral therapy (ART) during an acute infection to lower the virus in the blood of the monkey below a detectable level.
After a 96-week treatment, researchers divided the monkeys into four equal groups and administered ART for another 16 weeks to determine if the combination of HIV antibody and immunostimulant could reduce the virus reservoir while virus replication was performed
Following discontinuation of ART, the virus recovered in the blood of all 11 monkeys, who received neither HIV antibodies nor immune stimulants after an average of 21 days.
The experts also said six out of 11 monkeys Combination therapy showed a delayed viral rebound at median 112 days, and five others out of 11 did not recover for at least 168 days.
“Our findings point to the development of interventions to activate and eliminate a fraction that could allow the virus reservoir,” said Dan Barouch, lead researcher in the study.
The researchers said that compared to the antiretroviral therapy that must be taken daily, antibodies to HIV tend to last longer in the body and have shown promise for longer effective HIV therapeutics and prevention modalities